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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DENND1C All Species: 1.82
Human Site: S787 Identified Species: 4.44
UniProt: Q8IV53 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IV53 NP_079174.2 801 87065 S787 N C Q K S Q P S S R P R V A D
Chimpanzee Pan troglodytes XP_001138488 775 86507 I765 D F Q Q S L N I S D K N T N G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542137 887 96006 R873 D W Q G P Q A R S G P R V A E
Cat Felis silvestris
Mouse Mus musculus Q8CFK6 786 86671 V777 P Q D K Q P R V A D L K K C F
Rat Rattus norvegicus NP_001119761 546 59730 A538 Q D R Q P R V A D L K K C F E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517017 914 100669 L900 G D R D P E I L A L P R V S E
Chicken Gallus gallus XP_422194 839 93195 D828 Y G L N I S K D S L S S S S S
Frog Xenopus laevis Q68F67 1010 112359 T851 Q A L A A E K T A S V M G P P
Zebra Danio Brachydanio rerio Q6NXD8 1311 147682 R1224 L N S E S L C R Y V N A I N N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_397549 694 78747 S686 L N T P A I K S Q N N W T K F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 36.7 N.A. 73.5 N.A. 70.6 45.4 N.A. 51.3 37.4 34.9 20.2 N.A. N.A. 32.5 N.A. N.A.
Protein Similarity: 100 52.8 N.A. 77.7 N.A. 78.2 52 N.A. 62.4 53.6 49.1 32.1 N.A. N.A. 50.1 N.A. N.A.
P-Site Identity: 100 20 N.A. 46.6 N.A. 6.6 0 N.A. 20 6.6 0 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 33.3 N.A. 60 N.A. 20 40 N.A. 53.3 13.3 26.6 26.6 N.A. N.A. 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 10 20 0 10 10 30 0 0 10 0 20 0 % A
% Cys: 0 10 0 0 0 0 10 0 0 0 0 0 10 10 0 % C
% Asp: 20 20 10 10 0 0 0 10 10 20 0 0 0 0 10 % D
% Glu: 0 0 0 10 0 20 0 0 0 0 0 0 0 0 30 % E
% Phe: 0 10 0 0 0 0 0 0 0 0 0 0 0 10 20 % F
% Gly: 10 10 0 10 0 0 0 0 0 10 0 0 10 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 10 10 10 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 20 0 0 30 0 0 0 20 20 10 10 0 % K
% Leu: 20 0 20 0 0 20 0 10 0 30 10 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 10 20 0 10 0 0 10 0 0 10 20 10 0 20 10 % N
% Pro: 10 0 0 10 30 10 10 0 0 0 30 0 0 10 10 % P
% Gln: 20 10 30 20 10 20 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 20 0 0 10 10 20 0 10 0 30 0 0 0 % R
% Ser: 0 0 10 0 30 10 0 20 40 10 10 10 10 20 10 % S
% Thr: 0 0 10 0 0 0 0 10 0 0 0 0 20 0 0 % T
% Val: 0 0 0 0 0 0 10 10 0 10 10 0 30 0 0 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _